Using case studies in research differs from their use in teaching, where they are commonly called case methods and casebook methods . Teaching case studies have been a highly popular pedagogical format in many fields ranging from business education to science education. Harvard Business School has possibly been the most prominent developer and user of teaching case studies.   Business school faculty generally develop case studies with particular learning objectives in mind. Additional relevant documentation, such as financial statements, time-lines, and short biographies, often referred to in the case study as exhibits, and multimedia supplements (such as video-recordings of interviews with the case subject) often accompany the case studies. Similarly, teaching case studies have become increasingly popular in science education. The National Center for Case Studies in Teaching Science  has made a growing body of case studies available for classroom use, for university as well as secondary school coursework.  Nevertheless, the principles involved in doing case study research contrast with those involved in doing case studies for teaching. Teaching case studies need not adhere strictly to the use of evidence, as they can be manipulated to satisfy educational needs. The generalizations from teaching case studies also may relate to pedagogical issues rather than the substance of the case being studied.
Treatment of spiked bottles with sodium hydroxide demonstrated a negative effect on endotoxin; however the 3-log depyrogenation target could not be consistently achieved. Whilst the endotoxin in a number of bottles was reduced to a level below the acceptance limit, this was inconsistent. It should be noted that the caustic wash was performed by hand; hence the inconsistencies in depyrogenation may be linked to the variability of mixing. The mechanism of destruction during caustic treatment is due to the hydrolysis of ester and amide linkages found in the lipid A portion of endotoxin. The alkaline hydrolysis of ester linkages resulting in an alcohol and acid salt is called saponification and can be enhanced by heating . Therefore a greater reduction in endotoxin may have been achieved by including a heating stage in the caustic treatment.